In this dramedy, the darkness sometimes wins out over the laughs. For this list, we’re looking at the most gut-wrenching and heartbreaking moments from Showtime’s Shameless. As these moments feature crucial plot points, a spoiler warning is definitely in effect. Join MsMojo as we count down our picks for the Top 10 Saddest Shameless moments.

"Shameless" was never sad-less. For this list, we’ll be looking at the most heartbreaking moments surrounding the Gallagher family over the show's 11 seasons.

The best Fiona Gallagher Shameless moments demonstrate why this Showtime dramedy will never be the same without Emmy Rossum. We're taking a look at Fiona's defining moments from the first nine seasons of Shameless. In case you’re not caught up, keep in mind there will be spoilers. MsMojo ranks the best Fiona Gallagher Shameless moments. Which Fiona Gallagher moment is your favorite? Let us know in the comments!

These Lip Gallagher moments from Shameless are among the best moments in the entire series period. We’re taking a look at Lip Gallagher’s funniest, sweetest and most intense moments from the first nine seasons of the U.S. version of Shameless. No one in this family is perfect, but for better or worse, few try quite as hard as Lip! MsMojo ranks the best Lip Gallagher moments from Shameless. What’s your favorite Lip Gallagher moment? Let us know in the comments!

Love, heartbreak, and prison; these two have been to hell and back again. For this list, we’re looking at Ian Gallagher and Mickey Milkovich’s standout moments as "Shameless'" surprising but endearing ‘ship. Please be warned, spoilers ahead.