Welcome to MsMojo, and today we’re counting down our picks for the times Missy shone as Sheldon’s sister on “Young Sheldon” and the times Penny took on that role in “The Big Bang Theory.”

Lyric video for Surreal Sister by Cultural Vultures

Spread the love and these "Sister Act" franchise moments.

These "Sister Sister" moments were the envy of everybody without a twin.

We all know that blood is thicker than water, and these movies prove it with agonizing detail. If you have a sister, give her a big hug and never let her go - especially during these movies. We’re looking at the films that will tug at your heartstrings, resonating around the most important of female friendships - sisters. Both live action and animated films will be considered. Beware, there are some spoilers, heartaches and tears ahead. Join MsMojo as we countdown our picks for the Top 10 Movies That Will Wreck You if You Have a Sister.

Bluey and Bingo are #SisterGoals. For this list, we’ll be looking at a mixture of the most heartwarming and hilarious moments between the Heeler girls.

Official Music Video for "Surreal Sister" by Cultural Vultures.

In this http://www.WatchMojo.com video, we learn more about the comedy origins of American actress, comedian and television personality Whoopi Goldberg.

We’d gladly build a snowman with any of these animated Disney movie siblings.

Why is it that Cartoon Network villains seem to have all the fun? We’re taking a look at the most dastardly, humorous, and memorial baddies from animated Cartoon Network shows. We’ll be excluding live action, miniseries and characters from sister channels and related projects, like Adult Swim, however. WatchMojo ranks the best cartoon network villains. Who’s your favorite Cartoon Network villain? Let us know in the comments!

All the things that make us...cry! Welcome to WatchMojo, and today we’ll be looking at the most upsetting and heart-wrenching scenes from “Family Guy.” Some spoilers are bound to follow.

Best lock the door and make sure you're alone when watching these! Join Ashley as we look over the anime with the lewdest content

Whether good or bad, watching these anime is an ordeal! Join Ashley as we look over the anime that are difficult to sit through

Taking jabs at these series is practically recommended! Join Ashley as we look over the anime that are are all too easy to ridicule

Is she next in line to join the Avengers? For this video, we’re looking at the backstory of the woman who was meant to succeed Black Widow.