Top 10 Mad Scientists

Every mad doctor creates beasts, brutes and mutants, and it seems that’s exactly what Dr. Malavacqua does: he’s got a sex-crazed lady-vampire, a swamp monster and a Wolfman – not to mention the hunchbacked manservant and Frankenstein-type creature. While he’s got a bit of a Jekyll and Hyde thing going, his motives are actually pretty honorable: he’s trying to give the freaks normal lives. Didn’t see that coming!

He’s just a normal, genius-level scientist who creates a nuclear-powered suit with mechanical tentacles and artificial intelligence that goes haywire – it could happen to anyone! Of course, Doc Ock then ends up killing and thieving in order to see his experiment through to completion, which includes some serious Spider-Man beat downs. Fortunately good wins in the end, when he decides that suicide is the answer.

Jolly, kind and – let’s face it – super fat, Professor Klump is the kind of teacher any student would love, even with the klutziness and confidence issues. Outside the classroom, he’s conducting research to help obese people lose weight fast. With himself as the guinea pig, Klump tests his fat-reducing formula and slims way down, but becomes a real jerk in the process. We’ll consider this experiment a fail.

Though he’s been running from his family’s legacy, this doctor finally follows in the footsteps of his grandfather. With “Eye-gore” and Inga as help, Dr. “Fronk-en-steen” plunders graveyards and steals abnormal brains to reanimate his monster. Yadda-yadda-yadda, the creature escapes, angry mobs, tap dance routine, you know the drill. But he goes the extra mile to ensure his creation’s safe, and ends up a little wilder for his trouble.

Hailing from the planet Transsexual, he’s a murderous man-eater who swings both ways, and we guess has some sort of medical training? Motivated by sexual desire rather than scientific advancement, Dr. Frank-N-Furter is probably the only mad scientist you’ll see wearing pumps, lipstick and a garter belt. Based on that info, it’s not shocking to learn that in his lab, Frank produces a sexy, Speedo’d plaything for himself.

This bald-headed, cat-loving supervillain is a parody, but that doesn’t make him any less evil. Bent on world domination, he’s out of his time and his league, so his outlandish plans are always foiled. Throw in evil lairs, an estranged son, a tiny clone and frickin’ sharks with frickin’ laser beams attached to their heads and you’ve got the quintessential scheming mad doctor. Doctor of what, though, we’ll never know….

Founder and chief scientist at Muppet Labs, Dr. Honeydew is your typical absent-minded mad scientist-type, constantly putting his meepy assistant Beaker in harm’s way. His inventions usually help his friends get out of tight spots, but they often only have temporary results. During his hiatus from the Muppets, he took his sciencing skills to CERN – but how he works without eyeballs we still can’t figure out….

Unlikely scientists and even unlikelier heroes, the Ghostbusters share an interest in parapsychology, though each comes from a different background with different strengths. Venkman is the street-smart wisecracker who doesn’t have time for books, while Ray and Egon back him up with their academic prowess. Together, they figure out a way to bust ghosts, save the city and get the girl, all with unlicensed nuclear accelerators on their backs.

He’s considered a top scientific mind, but that doesn’t save Dr. Banner from his fate. After being exposed to gamma radiation in an experiment gone bad, he runs into a little problem – whenever his heart rate increases, he transforms into an angry green monster he struggles to control. That leaves him a part-time fugitive and a fulltime superhero, but at least he’s got friends to help him out.

Doc’s got the wild eyes, crazy hair, eccentric mannerisms and insane inventions necessary to be the most iconic movie mad scientist. Taking cues from his scientific idols, he throws his family fortune into his creations, including a cumbersome mind-reading device, automated breakfast-makers and – of course – the flux capacitor. Doc travels through space and time before deciding to devote himself to study the other great mystery of the universe: “women”.

Do you agree with our list? Which scientist do you think is the most mad? For more top 10s about your favorite flicks, be sure to subscribe to WatchMojo.com.